Xylometazoline Hydrochloride & Sodium Cromoglicate | MedexInfo
Xylometazoline Hydrochloride & Sodium Cromoglicate
OTC / Rx
Generic NameXylometazoline HCl & Sodium Cromoglicate
Therapeutic ClassDecongestant & Mast Cell Stabilizer
Common DoseNasal spray: 1-2 sprays per nostril up to 3x/day; Eye drops: 1 drop in affected eye 4x/day
PregnancyUse with caution
Indications ▼
Relief of nasal congestion due to allergic rhinitis or common cold
Prevention and relief of allergic conjunctivitis symptoms (eye drops)
Supportive treatment in sinusitis
Mechanism & Pharmacokinetics ▼
Xylometazoline: Alpha-adrenergic agonist; causes vasoconstriction in nasal mucosa, reducing swelling and congestion.
Sodium Cromoglicate: Stabilizes mast cells, preventing release of histamine and other inflammatory mediators; reduces allergy symptoms.
Pharmacokinetics: Xylometazoline minimally absorbed systemically; peak effect within 10–15 minutes. Sodium Cromoglicate is poorly absorbed; acts locally on mucosa/eye surface.
Dosage & Administration ▼
| Formulation | Recommended Dose | Frequency |
|---|---|---|
| Nasal Spray | 1-2 sprays per nostril | Up to 3 times daily, max 3 days |
| Eye Drops | 1 drop per affected eye | 4 times daily |
Note: Do not exceed recommended duration for decongestant to prevent rebound congestion; follow eye drop instructions carefully.
Side Effects ▼
Nasal spray: dryness, burning, sneezing, rebound congestion
Eye drops: stinging, irritation, redness, blurred vision
Rare: headache, dizziness, tachycardia (systemic absorption of xylometazoline)
Contraindications ▼
Hypersensitivity to Xylometazoline or Sodium Cromoglicate
Severe hypertension, coronary artery disease (nasal spray)
Children under 6 years (nasal spray)
Eye infections (eye drops)
Drug Interaction ▼
Monoamine oxidase inhibitors (MAOIs) may enhance systemic effects of xylometazoline
Other nasal decongestants may increase hypertension risk
Concurrent ophthalmic medications: avoid contamination and monitor compatibility
Pregnancy & Lactation ▼
Use nasal spray only if benefit outweighs risk; avoid prolonged use
Eye drops generally considered safe; consult physician
Clinical / Research Summary ▼
Therapeutic Role: Rapid relief of nasal congestion; prevention of allergic symptoms in eyes.
Clinical Effectiveness: Well established for short-term relief; mast cell stabilization reduces allergy recurrence.
Safety Profile: Safe for short-term use; monitor for local irritation and systemic absorption in sensitive populations.
Current Research: Combination sprays and optimized dosing intervals to maximize efficacy and reduce side effects.
Patient Counseling Points ▼
Use nasal spray only for 3 days consecutively to prevent rebound congestion.
Instill eye drops carefully; avoid touching tip to eye.
Report persistent irritation, redness, or systemic symptoms.
Store at room temperature, away from moisture and light.
Storage & Handling ▼
Store at 20–25°C, avoid freezing or excessive heat
Keep out of reach of children
Brand Names (Bangladesh & Global) ▼
Bangladesh (Local Brands):
Global / International Brands:
Medical Disclaimer: This information is intended for educational purposes only and must not replace professional medical advice.
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