Tibolone: Uses, Dosage, Side Effects & Brands | MedexInfo

Tibolone

Rx

Generic NameTibolone

Therapeutic ClassHormone Replacement Therapy (HRT)

Max / 24h2.5 mg

Common Dose2.5 mg once daily

PregnancyContraindicated

Indications ▼

Relief of menopausal vasomotor symptoms such as hot flushes and night sweats

Treatment of urogenital atrophy including vaginal dryness and dyspareunia

Improvement of mood changes and sleep disturbances associated with menopause

Prevention of postmenopausal osteoporosis in women at increased fracture risk

Improvement of sexual well-being and libido in postmenopausal women

Mechanism & Pharmacokinetics ▼

Mechanism: Tibolone is metabolized into active metabolites with estrogenic, progestogenic, and androgenic activity. These metabolites act selectively on target tissues to relieve menopausal symptoms without stimulating endometrium.

Pharmacokinetics: Rapid oral absorption. Extensively metabolized in liver. Active metabolites exert tissue-specific effects. Excreted mainly via urine and feces. Elimination half-life approximately 45 hours.

Dosage & Administration ▼

Indication	Dose	Frequency
Menopausal symptoms	2.5 mg	Once daily
Osteoporosis prevention	2.5 mg	Once daily

Note: Treatment should begin at least 12 months after last natural menstruation.

Side Effects ▼

Abdominal pain, nausea

Weight gain, fluid retention

Breast tenderness

Vaginal bleeding or spotting

Headache, dizziness

Contraindications ▼

Known or suspected breast cancer

Estrogen-dependent malignancies

Undiagnosed vaginal bleeding

History of venous thromboembolism

Severe liver disease

Pregnancy and lactation

Drug Interaction ▼

Enzyme inducers (rifampicin, carbamazepine): reduce effect

Anticoagulants: may alter coagulation response

Herbal St John’s wort: reduces efficacy

Pregnancy & Lactation ▼

Contraindicated in pregnancy

Not indicated during breastfeeding

Clinical / Research Summary ▼

Clinical Role: Alternative to conventional estrogen–progestin HRT for menopausal symptom control.

Benefit: Relieves vasomotor symptoms while minimizing endometrial stimulation.

Safety: Risk of stroke may increase in elderly women; use lowest effective dose.

Research Focus: Long-term cardiovascular and breast safety evaluation.

Patient Counseling Points ▼

Take tablet at the same time every day

Do not use before menopause is complete

Report any abnormal vaginal bleeding

Regular breast and gynecological check-up recommended

Storage & Handling ▼

Store below 25°C

Protect from moisture and light

Keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Bangladesh:

Menorest® 2.5 mg Renorma® 2.5 mg Tibilon® 2.5 mg Tibo® 2.5 mg Tibofem® 2.5 mg Tibomax® 2.5 mg Tibone® 2.5 mg Tibonor® 2.5 mg Tivion® 2.5 mg Ubilon® 2.5 mg

Global:

Livial Tibolone

Medical Disclaimer: For educational purposes only. Not a substitute for professional medical advice.

Reference Hubs:

• Drug Class: Hormone Therapy • Condition: Menopause • Condition: Osteoporosis