Allylestrenol: Uses, Dosage, Side Effects & Brands | MedexInfo

Allylestrenol

Rx Only

Therapeutic ClassProgestogen

Common Dose5–10 mg per dose

Max / 24h40 mg

PregnancyCategory N (Use only as prescribed)

Indications ▼

Prevention of threatened or habitual miscarriage

Management of gynecological disorders related to progesterone deficiency

Support in early pregnancy complications when prescribed by physician

Mechanism & Pharmacokinetics ▼

Mechanism: Synthetic progestogen; supports luteal function and maintains endometrial stability.

Pharmacokinetics: Rapid absorption after oral administration; metabolized in liver; excreted via urine and feces. Plasma half-life ~10 hrs.

Dosage & Administration ▼

Patient Category	Recommended Dose	Max / 24h
Pregnant women (threatened miscarriage)	5–10 mg orally, 2–3 times daily	40 mg
Habitual abortion prevention	5–10 mg orally, 2–3 times daily	40 mg
Gynecological disorders	Individualized dose, as prescribed	40 mg
Children / non-pregnant women	Use only if prescribed	40 mg

Side Effects ▼

Common: Nausea, headache, mild gastrointestinal upset

Rare: Allergic reactions, dizziness

Serious: Thrombophlebitis (very rare), hormonal imbalance

Contraindications ▼

Hypersensitivity to Allylestrenol or excipients

Undiagnosed vaginal bleeding

Severe liver dysfunction

Drug Interactions ▼

May interact with other hormonal therapies

Concurrent anticoagulants may require monitoring

Pregnancy & Lactation ▼

Use under medical supervision in pregnancy

Topical/systemic exposure during breastfeeding not well studied

Clinical / Research Summary ▼

Therapeutic Role: Allylestrenol is a synthetic progestogen primarily used to prevent preterm labor and recurrent miscarriage. It helps in maintaining pregnancy in women with luteal phase deficiency or threatened abortion.

Mechanism-Based Evidence: Allylestrenol exerts its effect by mimicking natural progesterone. It supports the endometrium, suppresses uterine contractions, and modulates the maternal immune response to favor embryo implantation and maintenance.

Clinical Effectiveness: Clinical studies indicate that Allylestrenol can reduce the risk of spontaneous abortion in selected patients, improve pregnancy continuation rates, and support fetal growth in cases of threatened preterm labor. Dosing is individualized based on gestational age and risk factors.

Safety Profile: Allylestrenol is generally well tolerated. Side effects may include mild nausea, headache, and breast tenderness. Long-term safety data in pregnancy show minimal risk to the fetus when used as prescribed.

Research Directions: Current research explores optimal dosing strategies, long-term outcomes in neonates, and the comparative effectiveness of Allylestrenol versus other progestogens in preventing preterm birth and recurrent miscarriage.

Patient Counseling Points ▼

Take orally with or after meals

Do not exceed prescribed dose (Max 40 mg/day)

Report unusual bleeding or hormonal side effects

Storage & Handling ▼

Store at 20–25°C, protect from light and moisture

Keep container tightly closed

Keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Bangladesh (Local Brands):