Roxatidine
Rx Only
GenericRoxatidine
Therapeutic ClassH2 Receptor Antagonist
Common Dose75–150 mg daily
Max / 24h150 mg
PregnancyCategory B
Indications ▼
Peptic ulcer (gastric and duodenal ulcers)
Gastroesophageal reflux disease (GERD)
Zollinger-Ellison syndrome
Prevention of stress-induced gastritis
Mechanism & Pharmacokinetics ▼
Mechanism: Roxatidine selectively inhibits histamine H2 receptors in gastric parietal cells, reducing gastric acid secretion and promoting ulcer healing.
Pharmacokinetics: Rapid oral absorption; peak plasma concentration ~1 hour; hepatic metabolism; excreted primarily via urine; half-life ~4–5 hours.
Dosage & Administration ▼
| Patient Category | Recommended Dose | Max / 24h |
|---|---|---|
| Adults (Ulcer) | 75 mg once daily at bedtime | 150 mg |
| GERD | 75 mg twice daily | 150 mg |
| Zollinger-Ellison Syndrome | 150 mg daily in divided doses | 150 mg |
| Elderly | 75 mg once daily; adjust if necessary | 150 mg |
Side Effects ▼
Common: Headache, diarrhea, constipation
Occasional: Dizziness, fatigue, nausea
Rare: Hepatic enzyme elevation, hypersensitivity reactions
Contraindications ▼
Hypersensitivity to Roxatidine or other H2 receptor antagonists
Severe liver dysfunction
Drug Interaction ▼
May increase plasma levels of drugs requiring gastric acidity for absorption
Minimal interaction with most other drugs
Pregnancy & Lactation ▼
Use only if clearly needed (Category B)
Excreted in breast milk in small amounts; use with caution
Clinical / Research Summary ▼
Ulcer Healing: Roxatidine promotes gastric and duodenal ulcer healing by reducing acid secretion.
GERD Symptom Control: Reduces heartburn, regurgitation, and esophagitis.
Safety Profile: Generally well tolerated; headache and mild GI upset are most common adverse events.
Current Research Focus: Comparative studies with other H2 blockers and PPIs for efficacy and long-term safety.
Storage & Handling ▼
Store at 20–25°C; protect from moisture & light
Keep out of reach of children
Patient Counseling Points ▼
How to take: Usually at bedtime, may be taken with or without food
Missed dose: Take as soon as remembered; do not double dose
Possible side effects: Headache, diarrhea, constipation
Monitor: Symptoms of ulcer or reflux; report severe side effects
Drug interactions: Inform healthcare provider of other medications
Lifestyle advice: Avoid NSAIDs, smoking, alcohol to enhance healing
Pregnancy and safety: Use only if prescribed by physician
Brand Names (Bangladesh & Global) ▼
Bangladesh (Local Brands):
Global / International Brands:
Roxicid
Roxat
Roxatidine
Medical Disclaimer: This clinical summary is for informational purposes only. Always follow guidance from a qualified healthcare professional for dosage, interactions, and use.
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