Paroxetine Hydrochloride
Rx Only
Generic NameParoxetine Hydrochloride
Therapeutic ClassSSRI Antidepressant
Common Dose20–40 mg once daily
Max / 24h50 mg
PregnancyCategory D
Indications ▼
Major depressive disorder (MDD)
Generalized anxiety disorder (GAD)
Social anxiety disorder (SAD)
Obsessive-compulsive disorder (OCD)
Panic disorder with or without agoraphobia
Mechanism & Pharmacokinetics ▼
Mechanism: Selectively inhibits serotonin reuptake in the CNS, increasing synaptic serotonin levels and improving mood and anxiety symptoms.
Pharmacokinetics: Well absorbed orally; peak plasma concentration in 5–8 h; extensively metabolized in liver (CYP2D6); half-life ~21 h; excreted mainly via urine.
Dosage & Administration ▼
| Patient Category | Recommended Dose | Max / 24h |
|---|---|---|
| Adults | 20 mg once daily in the morning or evening; may increase gradually to 40 mg/day | 50 mg |
| Elderly | Start with 10–20 mg once daily; titrate slowly | 40 mg |
| Adolescents (≥12 years) | 10–20 mg/day; titrate carefully | 40 mg |
| Hepatic/Renal Impairment | Use lower doses; monitor for adverse effects | As per physician guidance |
Note: Administer orally, with or without food. Avoid abrupt discontinuation to prevent withdrawal symptoms.
Side Effects ▼
Common: Nausea, headache, insomnia, dizziness, dry mouth, sweating
Occasional: Weight changes, sexual dysfunction, tremor
Rare: Serotonin syndrome, hyponatremia, bleeding tendency
Contraindications ▼
Hypersensitivity to paroxetine or any SSRI
Concomitant use with MAO inhibitors or within 14 days of stopping MAO inhibitors
Pregnancy risk (Category D); avoid unless benefits outweigh risk
Drug Interaction ▼
MAO inhibitors: risk of serotonin syndrome
Other serotonergic drugs: increased risk of serotonin syndrome
Warfarin: monitor INR
CYP2D6 substrates: plasma levels may be affected
Pregnancy & Lactation ▼
Category D; use only if benefit outweighs risk
Excreted in breast milk; monitor infant for adverse effects
Clinical / Research Summary ▼
Effective in reducing symptoms of depression, anxiety, OCD, and panic disorders.
Gradual onset; clinical benefits typically observed after 2–4 weeks.
Well-studied safety profile; monitor for serotonin syndrome and hyponatremia in high-risk patients.
Patient Counseling Points ▼
Take consistently at the same time each day.
Do not abruptly discontinue; taper under medical supervision.
Report any unusual bleeding, mood changes, or serotonin syndrome symptoms.
Avoid alcohol; caution with driving or operating machinery.
Storage & Handling ▼
Store at 20–25°C; protect from moisture and light
Keep tablets in original container
Keep out of reach of children
Brand Names (Bangladesh & Global) ▼
Medical Disclaimer: This information is for educational purposes only and should not replace professional medical advice. Always consult a qualified healthcare provider.
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