Albendazole
Rx / Oral
Therapeutic ClassBroad-Spectrum Anthelmintic
Common Dose400 mg single dose; up to 400 mg twice daily for certain infections
RouteOral
PregnancyCategory C – Avoid in first trimester
Indications ▼
Treatment of intestinal helminth infections: roundworm, hookworm, whipworm, pinworm
Treatment of systemic helminth infections: neurocysticercosis, hydatid disease
Used for prophylaxis in endemic areas in mass deworming programs
Mechanism & Pharmacokinetics ▼
Mechanism: Inhibits microtubule polymerization in parasites by binding to β-tubulin, disrupting glucose uptake and depleting energy stores, leading to parasite death.
Pharmacokinetics: Poor oral absorption; enhanced with fatty meals. Metabolized in liver to albendazole sulfoxide (active metabolite). Excreted mainly in urine. Half-life ~8–12 hours.
Dosage & Administration ▼
| Patient Group | Dose / Strength | Frequency |
|---|---|---|
| Adults / Children ≥2 yrs | 400 mg orally single dose | Once |
| Neurocysticercosis | 15 mg/kg/day | Divided into 2 doses for 8–30 days |
| Hydatid disease | 10–15 mg/kg/day | Divided into 2 doses for 1–6 months |
| Children <2 yrs | Use only if prescribed by pediatrician | As directed |
Side Effects ▼
Abdominal pain, nausea, vomiting
Headache, dizziness
Elevated liver enzymes, rare hepatotoxicity
Bone marrow suppression (rare, usually prolonged therapy)
Contraindications ▼
Hypersensitivity to albendazole or benzimidazole derivatives
Pregnancy (especially first trimester) unless benefits outweigh risks
Severe liver disease
Drug Interaction ▼
Cimetidine may increase albendazole plasma levels
Antiepileptics (phenytoin, carbamazepine) may reduce albendazole efficacy
Concurrent hepatotoxic drugs increase liver toxicity risk
Pregnancy & Lactation ▼
Category C – Avoid in first trimester; use only if necessary later
Use caution in breastfeeding; avoid if possible
Clinical / Research Summary ▼
Albendazole is highly effective against a wide range of nematodes and some protozoa.
Studies show cure rates of >95% for single-dose ascariasis and hookworm infections.
Albendazole sulfoxide is the active metabolite responsible for antiparasitic activity.
Long-term or repeated use may require liver function monitoring.
Patient Counseling Points ▼
Take with a fatty meal to improve absorption
Do not crush or chew tablets unless indicated
Complete full course even if symptoms improve
Report persistent abdominal pain, jaundice, or unusual bleeding
Storage & Handling ▼
Store at 20–25°C, protect from moisture and light
Keep container tightly closed
Keep out of reach of children
Brand Names (Bangladesh & Global) ▼
Medical Disclaimer: This clinical summary is for educational purposes only. Always consult a qualified healthcare provider before use.
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