Losartan Potassium + Hydrochlorothiazide | MedexInfo

Losartan Potassium + Hydrochlorothiazide

Rx

Generic NameLosartan Potassium + Hydrochlorothiazide

Therapeutic ClassARB + Thiazide diuretic combination

Common StrengthLosartan 50/100 mg + Hydrochlorothiazide 12.5/25 mg tablets

PregnancyContraindicated (2nd & 3rd trimester)

Indications ▼

Hypertension: For patients whose blood pressure is not adequately controlled by monotherapy with either losartan or hydrochlorothiazide alone.

Combination Therapy: Used to achieve target blood pressure in patients needing multiple agents.

Cardiovascular Risk Reduction: Helps reduce risk of stroke, myocardial infarction, and other hypertension-related complications.

Special Populations: Dose adjustment may be necessary in renal or hepatic impairment; caution in elderly.

Mechanism & Pharmacokinetics ▼

Mechanism: Losartan blocks angiotensin II type 1 receptors, reducing vasoconstriction, aldosterone release, and sodium retention. Hydrochlorothiazide inhibits sodium and chloride reabsorption in the distal tubules, increasing urine output and lowering blood pressure. The combination provides additive antihypertensive effect.

Pharmacokinetics: Losartan: peak plasma in 1–2 hours, metabolized to active EXP3174, half-life 2–6 hours; Hydrochlorothiazide: peak plasma 1–5 hours, excreted largely unchanged in urine, half-life ~6–15 hours.

Dosage & Administration ▼

Indication	Dose	Frequency / Notes
Hypertension (Adults)	Losartan 50 mg + Hydrochlorothiazide 12.5 mg	Once daily; may increase to Losartan 100 mg + HCTZ 25 mg if needed

Note: Monitor blood pressure, renal function, and serum electrolytes. Dose adjustments may be required in renal or hepatic impairment.

Side Effects ▼

Dizziness, hypotension

Hyperkalemia (mainly due to losartan)

Hypokalemia, hyponatremia (mainly due to HCTZ)

Fatigue, headache

Gastrointestinal upset: nausea, diarrhea

Photosensitivity (HCTZ)

Rare: angioedema

Contraindications ▼

Hypersensitivity to losartan, hydrochlorothiazide, or any component

Pregnancy (2nd & 3rd trimester)

Severe renal impairment or anuria

Severe hepatic impairment or cholestatic jaundice

History of angioedema related to ARBs

Drug Interaction ▼

ACE inhibitors or other ARBs: additive hypotension and hyperkalemia risk

Potassium supplements or potassium-sparing diuretics: hyperkalemia risk

NSAIDs: may reduce antihypertensive effect and increase renal risk

Other diuretics: additive blood pressure-lowering effect and electrolyte disturbances

Pregnancy & Lactation ▼

Contraindicated in second and third trimesters

Use during breastfeeding: caution advised; limited data available

Clinical / Research Summary ▼

Clinical Role: Combination therapy for hypertension when monotherapy is insufficient; provides additive antihypertensive effects.

Advantage: Effective blood pressure control, reduced cardiovascular risk; complementary mechanisms of ARB and thiazide.

Limitation: Electrolyte disturbances (hypokalemia, hyperkalemia), hypotension; requires monitoring.

Monitoring: Blood pressure, renal function, serum electrolytes, signs of angioedema.

Patient Counseling Points ▼

Take at the same time each day, with or without food

Do not stop therapy abruptly

Monitor blood pressure, kidney function, and electrolytes regularly

Report dizziness, swelling, unusual fatigue, or muscle cramps

Inform physician if pregnant or planning pregnancy

Storage & Handling ▼

Store below 30°C

Protect from moisture and light

Keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Bangladesh:

Losart Plus 50/12.5 mg Tablet Losart Plus 100/12.5 mg Tablet Osartan‑HZ Tablet Losatan HZ Tablet Losium Plus Tablet Lospil Plus Tablet Lotas Plus Tablet Osartil Plus Tablet Losardil Tablet Cardisan Plus Tablet CardoPlus Tablet Larb Plus Tablet Losapot Plus Tablet Pertilos Plus Tablet Precon Plus Tablet Preslow Plus Tablet Renosart Plus Tablet RePACE H Tablet SB‑Losak Plus Tablet

Global:

Hyzaar® Co-Diovan®

Medical Disclaimer: For educational purposes only. Not a substitute for professional medical advice.

Reference Hubs:

• Drug Class: ARBs • Drug Class: Thiazide Diuretics • Condition: Hypertension • Condition: Cardiovascular Risk Reduction