Risperidone: Uses, Dosage, Side Effects & Brands | MedexInfo

Risperidone

Rx

Generic NameRisperidone

Therapeutic ClassAtypical antipsychotic

Common Strength0.5, 1, 2, 3, 4 mg tablets; 1 mg/mL oral solution

PregnancyUse only if clearly needed

Indications ▼

Schizophrenia: Management of acute and chronic schizophrenia in adults and adolescents (13–17 years).

Bipolar Disorder: Treatment of acute manic or mixed episodes in adults and children (10–17 years).

Autistic Disorder: Treatment of irritability, aggression, and temper tantrums in children and adolescents (5–17 years).

Mechanism & Pharmacokinetics ▼

Mechanism: Antagonizes dopamine D2 and serotonin 5-HT2A receptors; modulates neurotransmission in the CNS to reduce psychotic symptoms.

Pharmacokinetics: Oral bioavailability ~70%; peak plasma 1–2 hours; metabolized via CYP2D6 to active metabolite 9-hydroxyrisperidone; half-life 3–20 hours; excreted renally.

Dosage & Administration ▼

Patient Category	Recommended Dose	Max / 24h
Adults (Schizophrenia)	2 mg orally twice daily; adjust to 4–6 mg/day	16 mg
Children/Adolescents (Schizophrenia)	0.5–1 mg orally twice daily; adjust to 3–6 mg/day	6 mg
Bipolar Disorder (Adults)	2–3 mg orally once daily; adjust to 6 mg/day	6 mg
Autistic Disorder (Children 5–17y)	0.25–0.5 mg orally once or twice daily; adjust slowly	3 mg

Note: Administer with or without food. Monitor for extrapyramidal symptoms, orthostatic hypotension, and metabolic changes. Adjust dose in renal or hepatic impairment.

Side Effects ▼

Extrapyramidal symptoms (tremor, rigidity)

Drowsiness, sedation

Weight gain, increased appetite

Orthostatic hypotension

Hyperprolactinemia (galactorrhea, menstrual changes)

Rare: Neuroleptic malignant syndrome, tardive dyskinesia

Contraindications ▼

Hypersensitivity to risperidone or any component

Severe CNS depression

Use caution in cardiovascular disease, history of seizures, or hepatic/renal impairment

Drug Interaction ▼

CYP2D6 inhibitors (fluoxetine, paroxetine): may increase risperidone levels

Other CNS depressants: additive sedation

Antihypertensives: additive hypotension

Pregnancy & Lactation ▼

Use only if clearly needed

Avoid during breastfeeding

Clinical / Research Summary ▼

Clinical Role: Effective atypical antipsychotic for schizophrenia, bipolar disorder, and irritability in autism.

Advantage: Less risk of EPS compared to typical antipsychotics; multiple formulations available.

Limitation: Risk of metabolic effects, hyperprolactinemia, and sedation; monitor patients regularly.

Monitoring: Weight, blood glucose, lipid profile, EPS symptoms, blood pressure.

Patient Counseling Points ▼

Take at the same time each day

Report abnormal movements, tremors, or muscle stiffness

Do not stop abruptly; consult physician before dose changes

Monitor blood sugar and weight regularly

Storage & Handling ▼

Store at 20–25°C

Protect from light and moisture

Keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Bangladesh:

Frenia® 1 mg Frenia® 2 mg Frenia® 4 mg Resco® 1 mg Resco® 2 mg Residon® 1 mg Residon® 2 mg Riscord® 1 mg Risdon® 1 mg Rislock® 1 mg Risperdex® 1 mg Rispolux® 1 mg Sizodon® 1 mg Sperdal® 1 mg Sperid® 1 mg Frenia® 1 mg/ml Oral Solution Residon® 1 mg/ml Oral Solution Risdon® 1 mg/ml Oral Solution

Global:

Risperdal®

Medical Disclaimer: For educational purposes only. Not a substitute for professional medical advice.

Reference Hubs:

• Drug Class: Atypical Antipsychotics • Condition: Schizophrenia • Condition: Bipolar Disorder