Lansoprazole: Dosage, Side Effects, Brands & Clinical Use | MedexInfo

Lansoprazole

OTC / Rx

Generic NameLansoprazole

Therapeutic ClassProton Pump Inhibitor (PPI)

Common Dose15–30 mg daily

Max / 24h60 mg

PregnancyCategory B

Indications ▼

Gastroesophageal reflux disease (GERD)

Peptic ulcer disease (gastric & duodenal)

Helicobacter pylori eradication (in combination therapy)

Zollinger-Ellison syndrome

Prevention of NSAID-induced ulcers

Mechanism & Pharmacokinetics ▼

Mechanism: Irreversibly inhibits H+/K+ ATPase (proton pump) in gastric parietal cells, suppressing gastric acid secretion.

Pharmacokinetics: Well absorbed orally; Tmax ~1.5 hrs. Bioavailability ~80%. Hepatically metabolized via CYP2C19 and CYP3A4. Elimination half-life ~1.5 hrs. Excreted in urine and feces.

Dosage & Administration ▼

Patient Category	Recommended Dose	Max / 24 Hours
Adults (GERD)	15–30 mg once daily, before meal	60 mg
Peptic Ulcer / H. pylori	30 mg daily in combination therapy	60 mg
Pediatric (≥1 yr)	15 mg daily	30 mg

Side Effects ▼

Common: Headache, diarrhea, nausea, abdominal pain

Less Common: Constipation, flatulence, dizziness

Serious: Hypomagnesemia, Clostridium difficile infection, osteoporosis-related fractures (long-term use)

Contraindications ▼

Hypersensitivity to lansoprazole or any PPI

Severe hepatic impairment (use caution)

Drug Interaction ▼

Clopidogrel: Reduced antiplatelet effect

Warfarin: May increase INR

Ketoconazole / Itraconazole: Reduced absorption due to reduced gastric acidity

Pregnancy & Lactation ▼

Generally considered safe (Category B)

Use with caution during breastfeeding

Clinical / Research Summary ▼

Acid Suppression Profile: Lansoprazole is a potent proton pump inhibitor that provides rapid and sustained inhibition of gastric acid secretion through irreversible blockade of the H⁺/K⁺-ATPase enzyme in parietal cells.

GERD and Ulcer Healing: Clinical trials demonstrate high healing rates in erosive esophagitis, duodenal ulcer, and gastric ulcer, with significant improvement in reflux-related symptoms.

H. pylori Eradication: Lansoprazole enhances antibiotic effectiveness in triple therapy by increasing intragastric pH, leading to improved eradication outcomes.

Rapid Symptom Relief: Compared with some PPIs, lansoprazole shows a relatively faster onset of acid suppression, which contributes to early symptom improvement.

Pediatric Evidence: Supported by clinical data for use in pediatric GERD and acid-related disorders, including oral disintegrating formulations for easier administration.

Drug Interaction Considerations: Metabolized mainly via CYP2C19 and CYP3A4; caution is advised with strong enzyme inhibitors or in poor metabolizers.

Long-Term Safety Data: Long-term observational studies indicate good tolerability, though extended therapy may increase risk of hypomagnesemia, vitamin B12 deficiency, and enteric infections.

Current Research Trends: Ongoing studies focus on step-down therapy, on-demand dosing in mild GERD, and comparison with newer acid-suppressing agents.

Patient Counseling Points ▼

Take 30–60 minutes before meals

Do not crush or chew capsules; swallow whole

Avoid excessive alcohol or NSAID use

Inform physician if taking other medications (especially antiplatelets)

Storage & Handling ▼

Store at 15–30°C, protect from moisture and light

Keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Bangladesh (Local Brands):

Lanzol Lanso Lanzo Lansoprazole ACME Lansopril Lanzop Lansocap Lanzol-15 Lanso-30 Lansopra Lanzop ACME Lanso Plus Lansol Lansoprazole Forte Lanzo ACME Lansop Lanzop-15 Lanso ACME Lansoprazole Plus Lansop-30

Global / International Brands:

Prevacid Takeda Lansoprazole Lanzor Longtec Lanso Lansoprazole Teva Lansoprazole Sandoz Lansoprazole Pfizer Lansoprazole Sun Lansoprazole Merck Lansoprazole 30 Lansoprazole 15 Prevacid Solutab Lansoprazole Ranbaxy Lansoprazole ICAP Lansoprazole Genpharm Generic Lansoprazole Lansoprazole USA Lansoprazole EU

Medical Disclaimer: This clinical summary is for informational purposes only. Always follow guidance from a qualified healthcare professional for dosage, interactions, and use.

Reference Hubs:

• Drug Class: Proton Pump Inhibitors • Conditions: GERD & Peptic Ulcer • Pathway: Gastric Acid Secretion